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While this approach is appropriate for capturing early oxidative and micronutrient-related alterations associated with disease severity, it does not allow evaluation of temporal dynamics, recovery patterns, or causal relationships, which would require longitudinal follow-up

Elevated homocysteine is only a sign that the MTHFR enzyme isnt working well and arsenic can contribute to this

Therefore, there is a growing interest in biosynthesized SeNPs, also due in part to their extraordinary biocompatibility, sustainability and affordability (251)